but since cannabis is illegal and your uncle may not wish to discuss it with his doctor... and since this is a very simple matter, here are my two cents. codeine when used for bowel reasons, is usually (but not always) used in lower doses than when it is used for pain. In addition if he takes the medicine regularly he will have most likely built a tolerance to the respiratory effects and primary mind altering effects (the ones to be worried about) but not necessarily the constipating effect (the effect the drug is most likely being used for). Therefore combining cannabis with his normal routine should produce minimal interaction and would likely not be dangerous, in fact it wouldn't be dangerous with any dose of any opioid that the patient is well-adjusted too. stopping the codeine for a few days is not a good idea for several reasons. First, the bowel effect the codeine provides will stop suddenly (which could get messy, and you don't want your uncle to stain his pants!) secondly when the codeine is started again a drop in tolerance due to the time away from the drug could lead to more serious impairment than normal when smoked with marijuana or alone. just my opinion.. and for the best advice i guess you should see your doctor like all these people say... but its not like you asked if you should start giving your uncle chemo-therapy or if you should cut off his leg...

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"I think that in human evolution it has never been as necessary to have this substance LSD... It is just a tool to turn us into what we are supposed to be." - Dr. Albert Hofmann ( ) at his 100th birth day party, January 11, 2006

"Marijuana- the cure for kids idle and destructive hours; let them stone themselves, not mailboxes" - me