Opie I agree with you vs your sis in regards to meds on an empty stomach. My personal feeling is that they work quicker and a little harder (depending on what the medicine is supposed to do) on an empty stomach than on a full one.
That being said....I don't worry too much whether my stomach is empty or not but if my stomach IS full I'll usually take an extra capsule to compensate. That seems to work fine for me and comes out about the same imo in the way I feel from the capsules. If you take them and wait a few hours before eating then the high seems less affected (it's already in your bloodstream) but I haven't really found food or a full stomach to affect things too much. I DO think they take a little longer to kick in on a full stomach so that may be a factor to some folks as well. Generally the capsules take between 1 and 1/2 to 2 hours to really start kicking in.
I'm someone with a pretty iron stomach but I know from Flameons great thread that the pills sometimes can cause stomach upset in some folks so it probably wouldn't hurt to drink a glass of milk or have a few crackers or something along that line to keep that at bay if you happen to have a senstive tummy. I personally keep both eyes open when I swallow.