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Interesting, caryophyllene is an ingredient found prominantly in black peppers. I had read studies that eating spicy peppers relieves pain, postulating that the spiciness is percieved by the brain as a type of "pain", thereby triggering an endorphine release. Maybe that wasn't the key after all.
There's also been some recent research indicating that the "runners high" isn't caused by endorphines as previously thought, but by your body's own cannabinoids. The previous endorphine theory had a problem with sufficient endorphine quantities penetrating the blood-brain barrier for the effect; apparently this problem wouldn't be so prevelant with a cannabinoid explanation. Which leads me to the question: would cannabis smokers, with all our highly decensitized cannabinoid receptors, be able to experience a runners high as effectively?
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"I think your love of the halfling's pipeweed has slowed your mind"
- Saruman
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